PRiORiTY - V2
Research type
Research Study
Full title
Platelet Research in Optimising Response in personalised antiplatelet Therapy for peripheral arterial disease (PRiORiTY).
IRAS ID
352793
Contact name
Badri Vijaynagar
Contact email
Sponsor organisation
University Hospitals of Leicester NHS Trust
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Peripheral arterial disease happens when blood flow to the legs is blocked by narrowed or clogged vessels. In its most serious form, called critical limb ischaemia, people can have bad pain, infections, ulcers, and might even lose a leg if not treated. A surgical procedure is often done to open the vessels and help blood flow again in the legs. But sometimes, the vessels get blocked again, or people may need more procedures, or even lose a leg.
To stop this from happening, patients are given blood-thinning tablets like aspirin or clopidogrel to help prevent blood clots. However, these tablets do not work well for everyone. This might be because of a part of the blood called platelets, which are not being properly stopped from forming clots. When the tablets do not work as they should, it can lead to worse outcomes, but we do not fully understand why this happens. There is a test called platelet function testing that can check how well these medicines are working, but it is not commonly used after procedures that open up blocked vessels.
This study will look at how well blood-thinning medicine affects things like how well platelets sticking together and forming clots, which causes vessels re-blockage, needing repeat procedures, or losing a leg. It will also try to find out why these medicine does not work well in some people. Patients having angioplasty will be asked to join the study, their blood will be tested to check how the medicine is working, and their health will be monitored for a year.
The study will help doctors figure out if testing how well blood-thinning medicines work on platelets to stop sticking together, this can help make better treatment plans, provide better care, and reduce problems for people with vessel blockages.
REC name
South East Scotland REC 01
REC reference
25/SS/0069
Date of REC Opinion
9 Oct 2025
REC opinion
Further Information Favourable Opinion