PRINCE Secondary (version 1)
Research type
Research Study
Full title
Persistent Physical Symptoms Reduction Intervention: a System Change and Evaluation in Secondary Care
IRAS ID
156145
Contact name
Trudie Chalder
Contact email
Duration of Study in the UK
2 years, 8 months, 30 days
Research summary
Pragmatic randomised controlled trial to evaluate the clinical and cost-effectiveness of a secondary care-based intervention which includes: (1) a joint clinic (JC) by an acute care specialist (e.g., neurologist / cardiologist / rheumatologist consultant/registrar/nurse) and a therapist (e.g., clinical psychologist / CBT therapist), but including cognitive behavioural components (CBT) (for which there is preliminary evidence of efficacy), and (2) up to 8 sessions of cognitive behavioural therapy (CBT) (minimum 4). This will be compared with treatment as usual (TAU). Participants will be adults with persistent physical symptoms (PPS) across three broad patient populations (i.e., fibromyalgia, non-cardiac chest pain and neurological symptoms). Randomisation will be stratified for clinic and disability. Follow-ups will be conducted at 9, 20, 40 and 52 weeks post-randomisation.
REC name
London - Camberwell St Giles Research Ethics Committee
REC reference
15/LO/0058
Date of REC Opinion
25 Feb 2015
REC opinion
Further Information Favourable Opinion