PRIME-ICH
Research type
Research Study
Full title
PRoteomics to Identify Markers of haematoma Expansion after IntraCerebral Haemorrhage (PRIME-ICH)
IRAS ID
172566
Contact name
Adrian Parry-Jones
Contact email
Sponsor organisation
The University of Manchester
ISRCTN Number
ISRCTN90048218
Duration of Study in the UK
1 years, 5 months, 30 days
Research summary
Stroke caused by a bleed within the brain; known as an intracerebral haemorrhage (ICH) accounts for up to 1 in 5 of all strokes. A high number of patients who suffer ICH die within the first few hours and more than half of those who do survive are left with long disability. In around a third of cases, further bleeding occurs in the brain within one day of onset. This is known as haematoma expansion and means it has grown in size. As the space within the skull is already tight, any swelling puts huge pressure of the brain itself, squashing it and causing further brain damage. Therefore a patient who initially appeared to be quite well can suddenly deteriorate and lose consciousness; often requiring emergency surgery to relieve the pressure within the brain. Finding a treatment to prevent haematoma expansion has proven difficult as by the time the symptoms present, it may be too late to show any real benefit. Whilst it is important to establish which patients are most at risk of haematoma expansion, current tests using signs on brain imaging have proved less than reliable; so this remains a target for researchers.
This study will collect data on patients who have suffered an ICH. Brain scans performed at admission (routine) and between 24-36 hours (research) will be compared. A blood sample obtained within hours of stroke will look for proteins that are present at much higher concentrations in the blood of those who develop haematoma expansion, compared to those who do not. These proteins might be useful markers for predicting who will get haematoma expansion, but we will need to conduct further larger studies to know this for sure and to devise a test that can be used in standard care.
REC name
North West - Haydock Research Ethics Committee
REC reference
15/NW/0387
Date of REC Opinion
28 May 2015
REC opinion
Further Information Favourable Opinion