Primary Graft Dysfunction in Lung transplantation
Research type
Research Study
Full title
Primary Graft Dysfunction in Lung transplantation – does surgical technique influence systemic inflammatory response
IRAS ID
197992
Contact name
John Dark
Contact email
Sponsor organisation
Newcastle upon Tyne Hospitals NHS Foundation Trust
Duration of Study in the UK
0 years, 8 months, 1 days
Research summary
Differing surgical techniques involved in lung transplantation exist and use of cardiopulmonary bypass is the most common. The Inflammatory response to the use of this has been questioned in the literature as contributing to early rejection of the transplanted organ. This research proposes the use of ECMO (a miniturized version of cardiopulmonary bypass with less of a systemic response) to see if it would reduce inflammatory effects and improve patient outcome. It is proposed that inflammatory markers would be sampled from a routine sputum sample at the end of the transplant would be compared in the two techniques. An audit of in-house clinical outcomes has already been performed and shows promising results.
REC name
North of Scotland Research Ethics Committee 1
REC reference
16/NS/0091
Date of REC Opinion
18 Oct 2016
REC opinion
Further Information Favourable Opinion