PRIDEHEART 1.0

• Research type

  Research Study

• Full title

  PRImary graft Dysfunction Evaluation in HEART Transplantation (PRIDE-HEART) study

• IRAS ID

  241344

• Contact name

  Prashant Mohite

• Contact email

  P.Mohite@rbht.nhs.uk

• Sponsor organisation

  Imperial College London

• Clinicaltrials.gov Identifier

  NA, NA

• Duration of Study in the UK

  3 years, 11 months, 31 days

• Research summary

  Primary graft dysfunction (PGD) is the most common cause of early deaths in patients with heart transplantation. The aetiology of PGD is multi-factorial and the aim of this study is to establish whether hearts maintained on the Organ Care System (OCS) express a profile of parameters that is predictive of graft function in recipient. In addition, the study aims to elucidate the fundamental metabolic and inflammatory mechanisms of PGD with different types of donor organ preservation techniques (e.g. cold storage or perfusion with warm oxygenated blood using the Organ Care System (OCS)). For this purpose, we will utilise electron microscopy and immunohistochemistry of myocardial biopsy samples, assessment of vascular and myocardial inflammation and injury based on blood and OCS perfusate samples, global metabolic profiling of endomyocardial biopsies and OCS perfusate samples by mass spectrometry and proteomic analysis of myocardial tissue.

• REC name

  North West - Haydock Research Ethics Committee

• REC reference

  20/NW/0191

• Date of REC Opinion

  5 May 2020

• REC opinion

  Further Information Favourable Opinion