Prevention of diabetes through a lifestyle intervention in children V1
Research type
Research Study
Full title
Prevention of Diabetes through a diet and physical activity intervention in overweight and obese children who are pre diabetic.
IRAS ID
160086
Contact name
Gareth Stratton
Contact email
Sponsor organisation
DRI
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
Type 2 diabetes, is one of the fastest growing chronic diseases worldwide. This is primarily due to increasing prevalence of obesity, caused by a sedentary and inactive lifestyle and general food abundance.
It is recognised now that many of the adult morbidities associated with metabolic disease originate in childhood. An increasing number of children around the world are laying the foundations for metabolic disease by being overweight, a well known predisposing factor for co-morbidities such as type 2 diabetes, liver disease and cardiovascular disease (Goran, 2003) This increasing prevalence of obesity in children poses a tremendous threat for future generations and an enormous economic burden, especially considering the fact, that childhood obesity is one of the biggest risk factors for adult obesity (Singh et al., 2008).
The PREVIEW project is a worldwide diabetes prevention project, which aims to investigate the most efficient lifestyle pattern for the prevention of type-2 diabetes in a population of pre-diabetic overweight or obese individuals. The objective of the intervention is to determine the preventative impact of a high-protein and low-GI diet in combination with moderate or high intensity physical activity on insulin resistance in predisposed, pre-diabetic populations by running a 2 year intervention delivered through group counselling meetings that based on psychological theory of behaviour change. There is convincing evidence from clinical trials that type 2 diabetes can be prevented or delayed through intensive lifestyle interventions that result in weight loss (Li et al., 2008; Lindström et al., 2006). However weight regain is common and jeopardises diabetes prevention. The recent FP6 DiOGenes Study identified two dietary factors that were associated with shorter-term prevention of weight regain after prior weight loss: higher protein intake and lower glycemic index (GI) (Larsen et al., 2012). However it is not known whether the proposed strategies are equally effective in children as in adults. Swansea University plans to use its wider involvement in the PREVIEW project and its paediatric expertise, together with involvement from the ABMU and conduct a sub study to the PREVIEW project that assess effect and feasibility of the PREVIEW intervention on pre-diabetic children aged 10-18 years old.REC name
Wales REC 6
REC reference
14/WA/1188
Date of REC Opinion
26 Nov 2014
REC opinion
Further Information Favourable Opinion