Prevention of chronic respiratory morbidity
Research type
Research Study
Full title
Prevention of chronic respiratory morbidity following premature birth
IRAS ID
173260
Contact name
Anne Greenough
Contact email
Sponsor organisation
King's College London
Duration of Study in the UK
1 years, 3 months, 0 days
Research summary
The cohort who will be studied were recruited into a study "Prediction of prematurely born infants at high risk of chronic respiratory morbidity". The prematurely born cohort had all their lower respiratory tract infections (LRTIs) in infancy documented. We intend to recall the children now aged 4 to 8 years to determine whether respiratory viruses, in particular rhinovirus, have increased their respiratory morbidity (troublesome respiratory symptoms requiring medication). Secondary aims are to determine whether the children are better able to undertake a novel non-volitional lung function test assessing the function of the respiratory muscles which does not require patient ability to perform the test compared to standard lung function tests, impulse oscillometry or spirometry and which test best identifies the response to bronchodilator treatment. Additionally, we wish to determine if a new definition of infant respiratory morbidity (cough, wheeze and need for respiratory medication at one year of age) compared to a diagnosis of bronchopulmonary dysplasia (chronic lung disease of prematurity, oxygen dependency at 28 days after birth) better predicts school age respiratory outcomes.
REC name
West Midlands - Coventry & Warwickshire Research Ethics Committee
REC reference
15/WM/0117
Date of REC Opinion
31 Mar 2015
REC opinion
Further Information Favourable Opinion