Prevalence of Acute and Chronic Kidney Disease in the ICU (PEACE)
Research type
Research Study
Full title
PrEvalence of Acute and Chronic Kidney Disease treated by renal replacement therapy in the ICU Environment (PEACE). A prospective international, multi-centre, prevalence study on the epidemiology of the use of renal replacement therapy for ICU patients who have acute kidney injury and chronic end stage kidney disease.
IRAS ID
171814
Contact name
Lui G Forni
Contact email
Sponsor organisation
European Society of Intensive Care Medicine Trials Group
Research summary
Acute kidney injury (AKI) is a common finding in intensive care unit (ICU) patients with up to 30 to 65% of patients experiencing an episode of AKI and furthermore 5% of ICU patients are treated with some form of renal replacement therapy. AKI is associated with important short term and long-term morbidity and mortality and is a considerable financial burden. Data on the use of renal replacement therapy (RRT) for AKI and for CKD in ICU patients are either on specific patient groups, survey based, or from a decade ago. Furthermore, these studies suffered from exclusion bias, as patients who fulfilled criteria for initiation of RTT, but who were denied RRT, were not considered. That this may be an important consideration as a recent small single centre study demonstrated similar mortality rate between patients with a similar degree of AKI who were and who were not treated with RRT. Therefore, the Acute Kidney Injury Network recommended measuring the epidemiology of AKI. We wish to assess the prevalence of severe AKI (defined as KDIGO class 3) and CKD (defined by treatment with renal replacement therapy (RRT)), in ICU patients, present at time of the study inclusion day.
Hopefully this will inform clinical practice particularly with respect to initiation of RRT.REC name
London - Hampstead Research Ethics Committee
REC reference
15/LO/0483
Date of REC Opinion
25 Mar 2015
REC opinion
Further Information Favourable Opinion