PrevAKI
Research type
Research Study
Full title
BIOMARKER GUIDED IMPLEMENTATION OF THE CARDIOVASCULAR SURGERY AKI BUNDLE GUIDELINES TO REDUCE THE OCCURRENCE OF AKI IN PATIENTS AFTER CARDIAC SURGERY
IRAS ID
233949
Contact name
Marlies Ostermann
Contact email
Sponsor organisation
Guy's & St Thomas NHS Foundation Hospital
Clinicaltrials.gov Identifier
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
After heart surgery, patients have a high risk of acute kidney failure, also known as acute kidney injury (AKI). At present, there is no cure for AKI, and management is limited to optimising the blood pressure and heart function, correcting dehydration and avoiding medications that could harm the kidneys.
The aim of this study is to find out whether early adherence with a bundle of treatment recommendations can help preventing the development of AKI in patients who are at high risk.
For this purpose, we plan to randomise (ie. similar to tossing a coin) high risk patients to standard care versus treatment according to a number of official recommendations. We will use a urine test to identify high risk patients.As per protocol, patients who agree to participate will have a urine test 4 hours after heart surgery. If the urine test is normal, no further actions will be taken. If the urine test indicates that they are at high risk of AKI, they will be randomised to either treatment according to a list of official recommendations for prevention for a duration of 12 hours or standard care. Treatment in the intervention group includes the optimisation of blood pressure and heart function, avoidance of harmful drugs and fluid treatment to correct any dehydration.
All other treatments will be decided by the clinical teams according to departmental practice.We will record whether there are important differences between both groups up to 90 days after surgery, including development of AKI, length of stay in hospital or need for dialysis.
REC name
South Central - Berkshire Research Ethics Committee
REC reference
18/SC/0161
Date of REC Opinion
1 May 2018
REC opinion
Unfavourable Opinion