PrePOSE
Research type
Research Study
Full title
Predicting the Pain Outcome of Surgery for Endometriosis (PrePOSE)
IRAS ID
349041
Contact name
Katy Vincent
Contact email
Sponsor organisation
University of Oxford / Research Governance, Ethics and Assurance
Clinicaltrials.gov Identifier
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Endometriosis is a chronic gynaecological condition that affects around 10% of women of reproductive age. This condition can cause debilitating pain, infertility, and poor quality of life. Endometriosis is a condition where endometrial-like tissue is present outside of the uterus which can cause inflammation around the pelvic area. Symptoms of endometriosis can consist of pain during the menstrual cycle, chronic pelvic pain, pain during sex, pain when urinating, pain when defecating, and fatigue. Current treatments for endometriosis consist of hormonal, anti-inflammatory and / or analgesic medications and laparoscopic surgery. Endometriosis is categorized into 4 stages (I – IV), with surgery often being the treatment suggestion for patients with stages III and IV. However, laparoscopic surgery does not always result in a reduction in pain for patients with endometriosis, therefore, it is important to try and understand which patients are most likely to benefit from surgery for their pain management. In the present study, patients with pelvic endometriosis at stage III or IV with planned surgical treatment scheduled will be recruited to the project. Participants taking part will provide data at 5 different time points: Time point 1 will consist of several baseline questionnaires, a physiological pain assessment, and a brain functional magnetic resonance imaging (fMRI) scan. Time point 2 will be the date of their endometriosis surgery, where a questionnaire will be taken, the surgery will be completed, and several biological samples will be taken. Time points 3 (3 months post-surgery), 4 (6 months post-surgery), and 5 (12 months post-surgery) will consist of completing online questionnaires. All data collected within this project will be used to investigate pain outcome following endometriosis surgery. This research is funded by NIHR BRC.
REC name
South East Scotland REC 02
REC reference
25/SS/0062
Date of REC Opinion
30 Sep 2025
REC opinion
Further Information Favourable Opinion