Prepare-ABC
Research type
Research Study
Full title
Supportive Exercise Programmes for Accelerating Recovery after major Abdominal Cancer surgery (PREPARE-ABC)
IRAS ID
200804
Contact name
James Hernon
Contact email
Sponsor organisation
Norfolk and Norwich University Hospitals NHS Foundation Trust
ISRCTN Number
ISRCTN82233115
Duration of Study in the UK
3 years, 5 months, 30 days
Research summary
Summary of Research
This trial is designed to look at whether an exercise intervention would be beneficial to patients pre and post hospital discharge when undergoing curative colorectal surgery. The trial is multi-centre, single blind (assessors only), 3-arm, randomised, controlled, recruiting colorectal cancer patients at point of diagnosis, within colorectal units in UK hospitals. \nColorectal cancer is the fourth commonest cancer in the UK, with 40,000 patients diagnosed per year. The current standard and best-proven treatment for this patient group is a surgical resection, with around 25,000 patients undergoing this procedure per year. A colorectal resection, while offering the best chance of survival, results in significant post operative morbidities (POMs).\nPOMs have psychological and health burdens for patients, but also impact greatly on healthcare resources and costs. Cost estimates show that post-surgical complications from colorectal surgery at least double the cost of post-operative care. Therefore interventions to reduce POMs could provide health benefits to patients and significant cost savings to the NHS. \n\nThe Improving Surgery Outcomes Group (ISOG) have reported a correlation between patient’s level of fitness and post-operative outcomes. Literature also reports that exercise training may improve fitness to a significant level even in the short period available between diagnosis and surgery. The role of pre and post-operative exercise hasn’t been extensively investigated, nor has the effectiveness of professionally supervised versus home based exercise programmes. Exercise advice is not yet routinely given to cancer patients. \nThis trial will compare standard care alone versus standard care plus supervised hospital based exercise and standard care plus supported home based exercise, undertaken 4 weeks pre-surgery and resuming 6 weeks post-surgery.Summary of Results
Awaiting publication of results.REC name
East of England - Essex Research Ethics Committee
REC reference
16/EE/0190
Date of REC Opinion
22 Jun 2016
REC opinion
Further Information Favourable Opinion