PREM-PLD V1.0
Research type
Research Study
Full title
Investigating Biomarkers of Prematurity-Associated Lung Disease
IRAS ID
361826
Contact name
Sailesh Kotecha
Contact email
Sponsor organisation
Cardiff University
Duration of Study in the UK
4 years, 11 months, 30 days
Research summary
We have recently established the concept of prematurity-associated lung disease (PLD) which can be accurately diagnosed from 5 years of age when spirometry is possible. However, it is important to more accurately diagnose PLD from early in life. Since spirometry is not possible until 5-6 years of age establishment of biomarkers for PLD at an earlier stage is an alternative method to identify at risk population. We have collected samples from preterm born infants in the first month of life in the AZTEC study and from school aged children (7-12 years old) from the RHiNO study. These studies have already established the outcome data of lung disease in both populations including identification of the lung disease bronchopulmonary dysplasia (BPD, also known as chronic lung disease of prematurity or CLD) and PLD in the school aged children thus can use biomarkers to not only understand the underlying disease processes but also identify if any biomarker can accurately identify future development of PLD.
REC name
London - Chelsea Research Ethics Committee
REC reference
25/PR/1127
Date of REC Opinion
18 Aug 2025
REC opinion
Favourable Opinion