Pregnancy outcomes in ANCA Associated Vasculitis v1.0 29.01.2026
Research type
Research Study
Full title
Investigating Maternal and Child Outcomes for Pregnancies in Anti-Neutrophilic Cytoplasmic Autoantibodies (ANCA) Associated Vasculitis v1.0 29.01.2026
IRAS ID
358988
Contact name
NINA BROWN
Contact email
Sponsor organisation
Northern Care Alliance NHS
Clinicaltrials.gov Identifier
25REN09-S, Northern Care Alliance NHS foundation trust
Duration of Study in the UK
0 years, 9 months, 31 days
Research summary
Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis (AAV) is a rare disorder that causes inflammation of blood vessels and can lead to damage of many organs/systems including kidneys, lungs, nerves, ears, nose and throat. It requires strong medication to control the immune system and as it is not a curable condition patients may need to stay on this for many years. AAV is a condition than can develop at any age meaning that for some patients this happens before or during their childbearing years. People can have successful pregnancies following a diagnosis of AAV but there is little information on whether having this condition or the medication leads to any health or development issues for the child. To allow us to better inform our patients with AAV who are considering pregnancy or find themselves pregnant we will collect information from patients in the region who have been diagnosed with AAV and then become pregnant. In the first instance we will use health care records, including maternity records, to record the outcomes of the pregnancy for mother and baby. Following this, mothers who consented to participation will be invited to answer two questionnaires. One questionnaire will collect information regarding the child’s health during the first five years of life (e.g. any history of long-term medical, hospitalisation, vaccinations status, early childhood education and child’s emotional wellbeing). The second questionnaire will be performed through a validated questionnaire, ITQOL-SF47, Infant Toddler Quality of Life Questionnaire Short Form 47 to collect information on the health and development of the child up to the age of 5 years. This is a validated questionnaire used to collect parent-reported health outcomes in infants/toddlers.
REC name
South Central - Oxford A Research Ethics Committee
REC reference
26/SC/0070
Date of REC Opinion
9 Mar 2026
REC opinion
Further Information Favourable Opinion