Predictors of treatment response in late-onset depression 1.0
Research type
Research Study
Full title
Predictors of treatment response in late-onset major depressive disorder
IRAS ID
178116
Contact name
Chavit Tunvirachaisakul
Contact email
Sponsor organisation
King's College London
Duration of Study in the UK
2 years, 5 months, 0 days
Research summary
Depression is a common disorder, especially in old age, where it is associated with significant morbidity and mortality. This study will investigate whether there are features of individual patients with major depression that may predict positive treatment response. The study will invite 40 patients who have been diagnosed with major depressive disorder with onset after the age of 60 years to participate. Participants will be recruited from the Mental Health of Older Adults services at the South London and Maudsley NHS Mental Health Foundation Trust. Participants will receive usual treatment as set out in standard Care Pathways, used by the clinical care team. As part of the study, they will undergo a short battery of neuropsychological tests and a standard MRI brain imaging protocol. The neuropsychological tests and assessment of depression severity will be carried out twice (at Baseline and Week 12). Data will be analysed to investigate whether there are features specific to those patients who show a good response to antidepressant treatment after 12 weeks. Identification of such predictors may help to stratify treatment approaches in the future and lead to the early identification of individual patients who may require alternative treatment approaches to standard antidepressants.
REC name
London - Bromley Research Ethics Committee
REC reference
15/LO/1033
Date of REC Opinion
11 Aug 2015
REC opinion
Further Information Favourable Opinion