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Predictors of treatment response in late-onset depression 1.0

  • Research type

    Research Study

  • Full title

    Predictors of treatment response in late-onset major depressive disorder

  • IRAS ID

    178116

  • Contact name

    Chavit Tunvirachaisakul

  • Contact email

    chavit.tunvirachaisakul@kcl.ac.uk

  • Sponsor organisation

    King's College London

  • Duration of Study in the UK

    2 years, 5 months, 0 days

  • Research summary

    Depression is a common disorder, especially in old age, where it is associated with significant morbidity and mortality. This study will investigate whether there are features of individual patients with major depression that may predict positive treatment response. The study will invite 40 patients who have been diagnosed with major depressive disorder with onset after the age of 60 years to participate. Participants will be recruited from the Mental Health of Older Adults services at the South London and Maudsley NHS Mental Health Foundation Trust. Participants will receive usual treatment as set out in standard Care Pathways, used by the clinical care team. As part of the study, they will undergo a short battery of neuropsychological tests and a standard MRI brain imaging protocol. The neuropsychological tests and assessment of depression severity will be carried out twice (at Baseline and Week 12). Data will be analysed to investigate whether there are features specific to those patients who show a good response to antidepressant treatment after 12 weeks. Identification of such predictors may help to stratify treatment approaches in the future and lead to the early identification of individual patients who may require alternative treatment approaches to standard antidepressants.

  • REC name

    London - Bromley Research Ethics Committee

  • REC reference

    15/LO/1033

  • Date of REC Opinion

    11 Aug 2015

  • REC opinion

    Further Information Favourable Opinion