Predictors of permanent pacemaker implantation post-TAVI at KCH
Research type
Research Study
Full title
Predictors of permanent pacemaker insertion following Transcatheter Aortic Valve Implantation; a single-centre retrospective study
IRAS ID
250386
Contact name
Philip MacCarthy
Contact email
Sponsor organisation
King's College Hospital NHS Foundation Trust
Duration of Study in the UK
0 years, 2 months, 0 days
Research summary
Until a decade or so ago, patients with symptomatic aortic stenosis who were deemed unfit for surgery could only be treated with medication. With the advent of less invasive techniques, elderly high surgical risk patients were able to have greater symptom relief than experienced with medication alone. As technology and operator skill progresses, less invasive aortic valve replacement is becoming more common in lower risk and younger patients. The rate of pacemaker insertion in the days following the procedure remains high. Research shows that the type of valve used and pre-existing abnormalities such as conduction disturbances can predict the need for a pacemaker. This project will examine which pre-existing abnormalities have led to pacemaker insertion following this type of less invasive aortic valve procedure at a large London teaching hospital. Data will be extracted from a pre-existing database of patients and anonymised prior to being viewed by the researcher. The data will then be used to populate a new database, and then analysed using statistical software. The results of this analysis may help to inform the type of valve used at this centre, in order to reduce the incidence of pacemaker insertion.
REC name
London - Brent Research Ethics Committee
REC reference
18/LO/1830
Date of REC Opinion
19 Oct 2018
REC opinion
Favourable Opinion