Predictors of late adverse affects after radiotherapy
Research type
Research Study
Full title
Predictors of late adverse affects after adjuvant radiotherapy in breast cancer patients
IRAS ID
172130
Contact name
Christopher. J. Talbot
Contact email
Sponsor organisation
University of Leicester
Duration of Study in the UK
20 years, 0 months, 0 days
Research summary
Radiotherapy is an extremely important treatment for breast cancer. A small number of people develop serious complications from this treatment. During the radiotherapy some patients develop red skin and the skin may peel off completely. Later there may be marked thickening of the tissues under the skin which is associated with chronic pain. The skin may also become thin, pale and contain prominent red tortuous blood vessels. There may be shrinkage of the breast.
These changes only occur in a minority of patients who may carry genes that predispose such people to radiation injury. Our long−term aim is to develop a test that would identify such vulnerable individuals in advance of any radiation treatment.
In this study we wish to investigate the link between a person's sleep-wake pattern and their risks of developing radiotherapy side effects. We will obtain information collected through completion of a questionnaire asking about a patient's sleeping habits. Following this we will invite some of the patients to donate a blood sample to look at their genetic profile specifically for genes relating to sleep-wake pattern to see if there is a link with radiotherapy toxicity.
REC name
London - Bromley Research Ethics Committee
REC reference
15/LO/0866
Date of REC Opinion
15 May 2015
REC opinion
Further Information Favourable Opinion