Predictive value of colonic manometry for intractable constipation
Research type
Research Database
IRAS ID
213908
Contact name
Osvaldo Borrelli
Contact email
Research summary
Research database for colonic manometry studies: in pursuit of predictive factors for intractable constipation
REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
16/YH/0494
Date of REC Opinion
29 Dec 2016
REC opinion
Further Information Favourable Opinion
Data collection arrangements
High amplitude propagated contractions (HAPCs) are the best indicator for colonic neuromuscular function. They are defined as contractions migrating for at least 15 cm in the colon with a certain peak amplitude of pressure. For each HAPC, amplitude (mmHg), duration (sec) and propagation (cm s-1) will be calculated. HAPCs will be then classified based on their propagation and shape.
Research programme
It is our aim to prospectively study and build a research database of patients suffering from intractable constipation referred to GOSH in order to identify manometric features of colonic neuromuscular dysfunction able to predict the outcome of the available treatments (either medical or surgical). Moreover, this research database might help us to better understand the underlying mechanisms of intractable constipation and hypothesise more effective treatments in the future.
Research database title
Research database for colonic manometry studies: in pursuit of predictive factors for intractable constipation
Establishment organisation
Division of Neurogastroenterology and Motilty, Department of Gastroenterology, Great Ormond Street Hospital
Establishment organisation address
Great Ormond Street
London UK
WC1N 3JH