Predictive biomarkers in patients with Barrett's oesophagus
Research type
Research Study
Full title
A study to investigate DNA aberrations, Telomere length, HPV, p53 and Her2/neu as adjunctive markers in Barrett's oesophagus surveillance and their ability in predicting progression to oesophageal adenocarcinoma.
IRAS ID
206047
Contact name
Ashraf Rasheed
Contact email
Sponsor organisation
ABUHB
Duration of Study in the UK
5 years, 5 months, 31 days
Research summary
Cancer of the gullet often presents late in its progress and as a result has very poor outcomes. A condition called Barrett’s oesophagus (BO) can happen before that gullet cancer takes hold and provides doctors with an opportunity to treat patients earlier.
As part of routine medical care, BO patients are regularly monitored by passing a camera into the gullet (endoscopy) and taking a small piece of tissue to examine under the microscope to check for early signs of cancer. Patients can find an endoscopy difficult to tolerate, and it is also costly. Furthermore, there is a degree of subjectivity rendering it less reliable.
We are trying to find a better way to monitor and diagnose cancer early for ‘at risk of cancer’ patients’. We are exploring the utility of a panel of tests that could help us to manage BO patients in a better way.
REC name
Wales REC 2
REC reference
16/WA/0214
Date of REC Opinion
22 Jul 2016
REC opinion
Unfavourable Opinion