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Prediction of stroke outcome using brain imaging machine-learning

  • Research type

    Research Study

  • Full title

    Optimizing prediction of stroke outcome using brain imaging machine-learning

  • IRAS ID

    204393

  • Contact name

    Paul Bentley

  • Contact email

    p.bentley@imperial.ac.uk

  • Sponsor organisation

    Imperial College London

  • Clinicaltrials.gov Identifier

    16517, UKCRN ID; 204393, IRAS ID

  • Duration of Study in the UK

    3 years, 0 months, 1 days

  • Research summary

    Thrombolysis (tPA) is the most efficacious and widely-used treatment for acute ischaemic stroke, but suffers a major complication rate of 2-10%, due to symptomatic intracranial haemorrhage (SICH). Developing methods that improve prediction of SICH can reduce harm, whilst also potentially increasing treatment opportunity for patients previously believed to be unsuitable. Current prognostication methods show only moderate accuracy (60-70% c-statistic) at predicting SICH; and are prone to high inter-rater variability, due to the need for radiological interpretation of acute brain (CT/MRI) images.

    Since the challenge of SICH prediction amounts to mapping a large number of high-dimensional inputs (imaging plus clinical variables), onto a dichotomous outcome, the problem lends itself well to computerized "machine learning" approaches that can optimally and automatically classify complex patterns. A well-known example of this technology is face, iris or fingerprint recognition scanners in airports. However machine learning, especially of images requires large datasets to train a model successfully for new cases, explaining why this study requires collection of thousands of previous cases from hospitals around the country.

    This project represents a cross-faculty, computer science – stroke medicine collaboration, to see whether machine learning can predict SICH as well as, or better than, current prediction methods. We aim to : 1) develop a computerized algorithm that relates early brain images to outcome (measured both functionally e.g. independence; and whether bleeding i.e. SICH occurred); and 2) test this algorithm on independent datasets.

    We envision that the software developed could be used in stroke centres around the world to stratify acute stroke patients for treatment more effectively than existing methods.

  • REC name

    Wales REC 3

  • REC reference

    16/WA/0361

  • Date of REC Opinion

    23 Nov 2016

  • REC opinion

    Further Information Favourable Opinion