Predicting outcomes following intervention for tricuspid regurgitation
Research type
Research Study
Full title
Predicting functional and clinical outcomes following transcatheter tricuspid valve intervention for severe tricuspid regurgitation
IRAS ID
340256
Contact name
Tiffany Patterson
Contact email
Sponsor organisation
King's College London
Duration of Study in the UK
4 years, 11 months, 23 days
Research summary
Blood flow leaking backwards across the heart’s tricuspid valve (regurgitation, TR) is a common problem. Until now, patients at high risk for surgery have been managed medically with no treatment options. However severe tricuspid valve regurgitation is associated with increasing death rates. More recently key-hole treatments have become available that can treat the heart valve without surgery. These include keyhole heart valve repair known as tricuspid transcatheter edge-to-edge repair (T-TEER) with a clip device, or keyhole heart valve replacement insertion of a replacement valve (TTVR): together these and other procedures are referred to as transcatheter tricuspid valve intervention (TTVI). How these patients respond to treatment is unclear, but a recent large randomised controlled trial suggested that patients ventricular TR do worse but the reasons behind this is unclear. Furthermore, by the time patients receive treatment, the heart is already failing and, we do not fully understand the impact on heart pump function following treatment. Complete eradication of the leak may cause pressure overload on the heart and cause it to worsen suddenly.
In order to address these questions, we will utilise non-invasive scans and collect pressure measurements from inside the heart at the time of patient’s procedures predict how patients’ heart pump function responds to treatment and therefore which patients might do better with TTVI. First, to determine the difference in treatment response between atrial and ventricular TR and understand the reasons why. Second, to determine the response of the heart pump function after treatment and if there are measurements or markers that would predict this response.
REC name
London - West London & GTAC Research Ethics Committee
REC reference
25/LO/0045
Date of REC Opinion
24 Feb 2025
REC opinion
Further Information Favourable Opinion