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PREDICT study (Personalised Responses to Dietary Composition Trial)

  • Research type

    Research Study

  • Full title

    Predicting inter-individual differences in biochemical and behavioral response to meals with different nutritional compositions using metabolomic and microbiome profiling\n

  • IRAS ID

    236407

  • Contact name

    Tim Spector

  • Contact email

    tim.spector@kcl.ac.uk

  • Sponsor organisation

    King's College London

  • Duration of Study in the UK

    3 years, 0 months, 1 days

  • Research summary

    The foods we eat – our diet – can affect whether we develop diseases during our lives, such as diabetes or heart disease. This is because the amount and types of foods we eat can affect our weight, and because different foods are metabolised (processed) by the body in different ways.\n \nScientists have also found that the bacteria in our guts (the gut microbiome) affects our metabolism, weight and health and that, together with a person’s diet and metabolism, could be used to predict appetite and how meals affect levels of sugar (glucose) and fats (lipids) found in blood after eating. If blood sugar and fat are too high too often, there’s a greater chance of developing diseases such as diabetes.\n \nThe gut microbiome is different in different people. Only 10-20% of the types of bacteria found in our guts are found in everyone. This might mean that the best diet to prevent disease needs matching to a person’s gut microbiome and it might be possible to find personalised foods or diets that will help reduce the chance of developing chronic disease as well as metabolic syndrome. \n \nWe are recruiting volunteers aged 18-65 years to take part in a study that aims to answer the questions above. We will ask volunteers to come for a clinical visit where they will give blood, stool, saliva and urine samples. We will also give volunteers a standardised breakfast and provide them with a glucose monitor to monitor their blood sugar levels. After the visit, we will ask volunteers to eat standardised meals at home for breakfast for a further 10 days. We will also ask them to prick their fingers at regular intervals to collect small amounts of blood, and to record constantly their appetite, food, physical activity and sleep using apps and wearable devices.

  • REC name

    London - Hampstead Research Ethics Committee

  • REC reference

    18/LO/0663

  • Date of REC Opinion

    20 Apr 2018

  • REC opinion

    Favourable Opinion