PRospective Evaluation of Interstitial Lung DIsease progression with quantitative CT (PREDICT-ILD)
University of Exeter
Duration of Study in the UK
1 years, 5 months, 30 days
The interstitial lung diseases (ILD) are a heterogenous group of conditions with varying degrees of inflammation and scarring (fibrosis) of the lungs. ILD progression is unpredictable, making prognostication challenging. A proportion of patients will develop inexorably progressive disease termed progressive fibrosing ILD (PF-ILD).
We will undertake a feasibility study to determine whether baseline and longitudinal quantitative assessment of high-resolution CT scans (HRCT) can predict and quantify disease progression in fibrotic-ILD.
We will also assess the role of several new ways of predicting and monitoring disease progression including:
• Assessment of the endothelial glycocalyx (EG), a mesh-like layer that lines the small blood vessels, which has been implicated in non-thoracic fibrotic diseases.
• Measurement of white blood cell telomere lengths; telomeres are repetitive genetic sequences which cap chromosomes which are shortened in a wide range of ILDs.
• A digital stethoscope assessment which records and analyses breath sounds
36 adult participants with fibrotic-ILD and 18 healthy volunteers from 3 centres in England will be recruited. Case (disease) participants will undergo investigations at 0, 6 and 12 months from recruitment including:
2. Lung function testing
3. EG, telomere length and digital stethoscope assessment
4. Health related quality of life assessments
Healthy controls will undergo the investigations in point 3.
The primary outcome will assess the correlation of disease progression status measured by standard of care (FVC) with baseline qCT, telomere and EG assessment. Feasibility outcomes will be assessed including recruitment, consent and attrition rates.
The results will inform a subsequent multi-centre study to assess the clinical benefit of disease monitoring with the measures assessed in this study.
15 participants will be invited to a sub-study to investigate the role of a specialised scan (SPECT-CT scan) to identify patients at risk of disease progression.
North West - Preston Research Ethics Committee
Date of REC Opinion
21 Feb 2023
Further Information Favourable Opinion