PREdiCt Ablation STrategy for Atrial Fibrillation (PRECAST-AF)

• Research type

  Research Study

• Full title

  Development of patient-specific tools to determine the need for adjunctive ablation following PVI for persistent AF using detailed characterisation of the substrate and the mode of recurrence

• IRAS ID

  186535

• Contact name

  Nick Linton

• Contact email

  nick.linton@imperial.ac.uk

• Sponsor organisation

  Imperial College London

• Duration of Study in the UK

  2 years, 11 months, 31 days

• Research summary

  Atrial fibrillation (AF) is a common heart rhythm abnormality which results in an irregular heart beat. Cardiac ablation is a treatment involving the placement of specialised catheters within the heart chambers to make a series of small burn marks in attempt to restore a normal heart rhythm. The current methods for patients in long term AF result only in only around a ~40% success rate after 1 procedure. This, at least in part, is likely to be due to a poor understanding of this group of patients, and therefore what the best method of cardiac ablation might be. In order to gain a better understanding we plan to better characterise the underlying mechanisms driving ongoing AF by using patient specific data collected during an ablation procedure to generate computer predictions and simulation to identify the likelihood and mode of recurrence.

• REC name

  London - Fulham Research Ethics Committee

• REC reference

  16/LO/1263

• Date of REC Opinion

  26 Sep 2016

• REC opinion

  Further Information Favourable Opinion