Prebiotics in Immunity and Inflammation V1

• Research type

  Research Study

• Full title

  Prebiotic effect on markers of peripheral immunity and inflammation in gastrointestinal inflammation

• IRAS ID

  208755

• Contact name

  Kevion Whelan

• Contact email

  kevin.whelan@kcl.ac.uk

• Sponsor organisation

  King's College London

• Duration of Study in the UK

  0 years, 9 months, 14 days

• Research summary

  This study will investigate the effect of six weeks supplementation with a prebiotic galactooligosaccharide food supplement on markers of gastrointestinal immune activation and inflammation in the blood, stool and urine. The prebiotic food supplement will be given daily alongside standard therapy in moderate gastrointestinal inflammation as seen in mildly active ulcerative colitis. This will be a broad spectrum exploratory study which will inform the direction of future research into the complementary therapy of prebiotic food substances in conditions with increased overt and subclinical inflammation such as inflammatory bowel disease, obesity, diabetes, irritable bowel syndrome and in aging.

• REC name

  Yorkshire & The Humber - Bradford Leeds Research Ethics Committee

• REC reference

  16/YH/0438

• Date of REC Opinion

  4 Oct 2016

• REC opinion

  Favourable Opinion