PRE18FFIR-REPRO
Research type
Research Study
Full title
Prediction of Recurrent Events with 18F-Fluoride to Identify Ruptured and High-risk Coronary Artery Plaques with Myocardial Infarction - REPROducibility Substudy
IRAS ID
172278
Contact name
David Newby
Contact email
Duration of Study in the UK
3 years, 7 months, 3 days
Research summary
Heart attacks are caused by a blood clot which stops blood flowing to part of the heart muscle. The blood clots form in areas of blood vessels (arteries) that are damaged (inflamed) by a build up of small fatty lumps (plaques). The fatty lumps can break and cause blood to stick to the wall of the blood vessel. It appears that this process can also occur without causing any symptoms and may put patients at increased risk of heart attacks in the future. It has also been shown that patients with a heart attack often have more than one damaged plaque. Previous research has shown a specialised scanner known as a PET (positron emission tomography) scan can identify these damaged plaques in patients with a recent heart attack using the tracer 18F-sodium fluoride. We intend to see if the presence of 18F-sodium fluoride plaques can be used to predict heart attacks in the future. This study will involve patients undergoing two PET scans over a short time period to determine whether the images obtained are sufficiently reproducible to support widespread adoption of this imaging method.
REC name
South East Scotland REC 02
REC reference
15/SS/0203
Date of REC Opinion
20 Nov 2015
REC opinion
Favourable Opinion