PRE-OP ENERGY TRIAL
Research type
Research Study
Full title
A RANDOMISED CONTROLLED TRIAL OF A PRE-OPERATIVE HIGH ENERGY DIET FOR THE PREVENTION OF ORGAN INJURY IN CARDIAC SURGERY: THE PRE-OP ENERGY TRIAL
IRAS ID
246009
Contact name
Gavin J. Murphy
Contact email
Sponsor organisation
University of Leicester
Duration of Study in the UK
3 years, 3 months, 0 days
Research summary
Organ injury is a common and often life-threatening complication of heart surgery. Decades of research have failed to identify effective ways to prevent organ injury after heart surgery.
In recent studies we have demonstrated that baseline cardio-metabolic status (for example, factors such as whether an individual is normal weight, overweight or obese, or has high or low blood pressure) is an important determinant of organ injury. We now wish to establish whether pre-surgery interventions that alter baseline metabolic state can protect organs during and after heart surgery.Overweight and obese heart surgery patients have lower rates of organ failure and in-hospital death compared to normal or underweight patients. This is referred to as the ‘obesity paradox’.
We have previously demonstrated that an 8-12 week high energy, high fat diet protects against kidney and heart injury in an animal study in pigs.The PRE-OP ENERGY trial will investigate the mechanisms underlying the ‘obesity paradox’ and establish whether a pre-surgery high energy, high fat diet for 8 to 12 weeks will have organ protection effects in humans.
REC name
East Midlands - Leicester Central Research Ethics Committee
REC reference
18/EM/0254
Date of REC Opinion
17 Sep 2018
REC opinion
Favourable Opinion