Pre-MAMMOTH-HF
Research type
Research Study
Full title
Preparatory work for a multi-arm, multi-stage trial of adjunctive treatments in patients hospitalised with heart failure (Pre-MAMMOTH-HF): Consensus building - what would a future trial look like? - Application for the patient and carer panel.
IRAS ID
363484
Contact name
Joe Cuthbert
Contact email
Sponsor organisation
Research and Development
Duration of Study in the UK
1 years, 3 months, 0 days
Research summary
Why is this research important?
Heart failure happens when the heart can’t pump blood properly, causing fluid to build up in the body. This leads to breathlessness and leg swelling, and is a common reason for hospital admission. Treatment is with furosemide, a drug given through a drip to help remove excess fluid. However, furosemide can have side effects and doesn’t always work well. Many patients stay in hospital for over a week, and around one in four are readmitted within a month of going home. There is an urgent need to improve treatment so people can recover faster, spend less time in hospital, and have better outcomes
after discharge.What is this study trying to do?
We are planning a large clinical trial to test new combinations of treatments alongside furosemide for people admitted to hospital with heart failure. But first, we need to answer several key questions in this early phase of the research:
1. Which treatments should be tested, at what dose, and for how long?
2. What is the best dose of furosemide to use as a comparison?
3. What outcomes should be measured (e.g. fluid loss, time in hospital)?
4. How many people could take part, and which hospitals can run the trial?How will we do this?
• An online survey will ask UK heart failure specialists about treatment options and their hospital’s ability to take part.
• An expert panel of 20–25 clinicians will review the evidence and help design the trial.
• The purpose of this application: a patient and carer panel will share views based on their experiences of heart failure and hospital care. Their feedback will help decide which treatments and outcomes matter most.REC name
South West - Central Bristol Research Ethics Committee
REC reference
25/SW/0139
Date of REC Opinion
13 Nov 2025
REC opinion
Favourable Opinion