PRAGMATIC-DCE
Research type
Research Study
Full title
PRecision biomArker-Guided MAnagement of TuberculosIs Contacts: a Discrete Choice Experiment
IRAS ID
349011
Contact name
Rishi Gupta
Contact email
Sponsor organisation
University College London
Duration of Study in the UK
1 years, 5 months, 30 days
Research summary
This study is part of a broader programme of work to develop and pilot a randomised-controlled trial of new tests to identify people who will benefit most from preventive treatment for tuberculosis (TB). The aim of the current study is to explore factors affecting patient decisions to start preventative treatment. The specific objectives are to understand how patients make decisions about preventative treatment; and to develop and conduct a "discrete choice experiment" survey to further explore factors that influence decisions. In this study, we will perform up to 30 semi-structured interviews among people undergoing testing for "latent" TB infection (LTBI), as part of routine clinical screening programmes (stage 1). Latent TB infection is when a person has been infected with the bacteria that cause TB but their immune system controls the infection, without any symptoms of illness. Adults (aged ≥18 years) who have been or are being tested for LTBI in routine clinical services will be eligible for inclusion. The findings from the qualitative study will be used to inform the development of a discrete choice experiment (DCE; stage 2). The DCE will be conducted to assess how preventative treatment acceptance might change according to an individual's future risk of TB, from patient and healthcare provided perspectives.
REC name
London - Brighton & Sussex Research Ethics Committee
REC reference
25/LO/0125
Date of REC Opinion
25 Mar 2025
REC opinion
Further Information Favourable Opinion