PPGR in T1D - Version 1
Research type
Research Study
Full title
Assessing interpersonal variability in postprandial glucose responses to food in people with type 1 diabetes
IRAS ID
308018
Contact name
Matthew Campbell
Contact email
Sponsor organisation
University of Sunderland
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Type 1 diabetes (T1D) is a lifelong disease which stops the body from producing insulin – an important hormone that controls blood sugar (glucose) levels. People with T1D use insulin replacement therapy, usually in the form of injections, to help control blood glucose levels, however keeping glucose levels within normal ranges is usually a challenge. Mealtime glucose control is fundamental to good diabetes management and are an important contributor to long-term diabetes complications. However, many individuals experience variability in glucose levels around mealtimes. The objective of this study is to establish whether and which parameters are important predictors of mealtime glucose levels in people with T1D.
We will monitor glucose levels using the latest glucose monitoring technology and collect blood samples to:
1. Characterise changes in glucose levels in individuals with T1D in response to different meals
2. Determine whether and what food characteristics and personal factors are linked to individual glucose responses to different meals.We will recruit 150 individuals with type 1 diabetes. Firstly participants will attend a preliminary visit, where a blood sample will be donated to study laboratory blood markers of vascular and metabolic health accompanied by a full medical examination in which body composition will be established. During this visit participants will also complete questionnaires about their lifestyle, and be fitted with two wearable devices to monitor glucose levels and physical activity levels under free-living conditions.
After 4-weeks of wearing the devices, participants will attend two experimental laboratory visits where breakfast and lunch will be served and blood samples taken. This will enable us to observe glucose and metabolic responses to feeding under controlled conditions.
REC name
Wales REC 7
REC reference
21/WA/0381
Date of REC Opinion
29 Nov 2021
REC opinion
Further Information Favourable Opinion