Postoperative fibrinolysis in inherited bleeding disorders
Research type
Research Study
Full title
To assess the postoperative changes in fibrinolysis and the utility of tranexamic acid in patients with inherited bleeding disorders.
IRAS ID
295131
Contact name
Beverley Hunt
Contact email
Sponsor organisation
Guys and St Thomas's Foundation NHS Trust
Duration of Study in the UK
0 years, 11 months, 29 days
Research summary
Previous studies have shown that 24 hours after surgery the process of clot breakdown (fibrinolysis) shuts down. Tranexamic acid is a medication which inhibits fibrinolysis. Despite this, for many years patients with an inherited bleeding disorder have been given tranexamic for 5 days postoperatively. We hypothesize that use of tranexamic acid, beyond 24 hours post-operatively is unnecessary. We aim to perform a prospective trial assessing (a) laboratory markers of clot break down and (b) the effect of one versus five days of tranexamic acid in patients with inherited bleeding disorder.
REC name
London - Camden & Kings Cross Research Ethics Committee
REC reference
22/LO/0034
Date of REC Opinion
4 Feb 2022
REC opinion
Favourable Opinion