Postoperative electrical muscle stimulation (POEMS) - 2
Research type
Research Study
Full title
A Three-Arm Randomised Controlled Trial to Establish Effectiveness of Neuromuscular Electrical Stimulation (NMES) With or Without Protein Supplementation to Preserve Muscle Mass and Strength and Improve Functional Outcomes After Abdominal Surgery for Gastrointestinal Cancer
IRAS ID
347923
Contact name
Bethan Phillips
Contact email
Sponsor organisation
University of Nottingham
Duration of Study in the UK
1 years, 5 months, 1 days
Research summary
Undesirable loss of skeletal muscle mass (atrophy) is a common feature of many diseases as well as ageing, bed rest and physical inactivity. Losing muscle can lead to a reduction in one’s ability to perform physical activities, and reduce independence and overall health. Muscle mass loss occurs very quickly (i.e., within a few days) after surgery even in the current setting of advanced recovery protocols after surgery.
We have recently shown that neuromuscular electrical stimulation (NMES) of the thigh muscles on one side of the body can help maintain muscle mass and strength on the stimulated side after surgery. Since then, we have run a study with healthy volunteer participants to find the most effective form of stimulation to build muscle.
The current study aims to use this refined stimulation protocol in a clinical trial on the wards of Royal Derby Hospital after major abdominal surgery.
All patients participating will have standard post-operative mobilisation and care. The control group will receive this standard care with no additional intervention. The "NMES" group will receive twice daily, 30-minute sessions of NMES to both thighs as well as a placebo drink (flavoured but no protein content). The "NMES" group will receive the same NMES training as well as protein supplement drink (to provide 60 g of protein per day).
The aim of the study is to assess whether this stimulation can preserve muscle mass and strength, and also, patients’ ability to perform physical activities after surgery. In addition, we want to find out whether any benefit provided by electrical stimulation can be increased further by additional protein intake.REC name
London - Surrey Research Ethics Committee
REC reference
24/LO/0876
Date of REC Opinion
21 Jan 2025
REC opinion
Further Information Favourable Opinion