POSH project
Research type
Research Study
Full title
Prospective observational study of glaucoma patients with disc haemorrhages. Analysis of systemic and local factors related with the presence of a new disc haemorrhage.
IRAS ID
227445
Contact name
David F Garway-Heath
Contact email
Sponsor organisation
Moorfields Eye Hospital NHS Foundation
Duration of Study in the UK
1 years, 4 months, 20 days
Research summary
Glaucoma is the most common cause of irreversible blindness in the world. It affects the optic nerve (which connects the eye to the brain) and can progress to visual impairment at very different speeds between patients. Therefore, it would be ideal to identify characteristics that help doctors predict the patients that are more likely to progress in the short term. Some people with glaucoma develop a small bleeding in the optic nerve which has been found more frequently in patients with progression of the disease. This bleeding could be a sign that the circulation of blood is abnormal in the optic nerve and in other parts of the body like the nailbed. It has already been shown that some patients with bleedings in the optic nerve also develop bleedings in the nailbed and this might be because both receive blood from very small vessels called capillaries. The objective of this study is to observe the changes in the eye, the nailbed microcirculation and the symptoms of patients during and after a newly identified optic nerve bleeding. We will include patients with primary open angle glaucoma with new optic nerve bleeding that attend the glaucoma clinics at Moorfields eye hospital. During a year the participants will attend 5 visits to identify changes in the optic nerve bleeding, the microcirculation of the eye and nailbed, the visual field, the quality of life and the symptoms related to abnormal circulation. This information will help us better understand the impact that these small bleeding have in patients with glaucoma and how they are related with progression of glaucoma.
REC name
West Midlands - Edgbaston Research Ethics Committee
REC reference
17/WM/0458
Date of REC Opinion
25 Jan 2018
REC opinion
Further Information Favourable Opinion