Porto-venous Radiomics in Pancreatic Cancer
Research type
Research Study
Full title
Porto-venous Radiomics in Pancreatic Cancer: A multi-centre retrospective cohort study investigating the use of pre-operative CT radiomic features to predict surgical resection margin in pancreatic head malignancy
IRAS ID
306452
Contact name
Ricky Bhogal
Contact email
Sponsor organisation
The Royal Marsden NHS Foundation trust
Clinicaltrials.gov Identifier
00, 00
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Pancreatic cancers are often inoperable at diagnosis, with only 13-22% of patients being suitable for surgical resection. Surgery is the only curative option, however a majority of those who undergo surgery will suffer from recurrence. This is due to the difficulty in removing the tumour fully, often with microscopic amounts left behind, and the proximity of the pancreas to blood vessels supplying the intestines and liver that cannot be easily removed. An assessment of whether microscopic tumour remains is known as the “resection margin”, and this has been correlated to overall survival after surgery.
The field of Radiomics, which has emerged over the past 10 years, looks to extract and analyse large amounts of information not usually visible to the human eye from medical images, and is increasingly used in the field of cancer diagnostics. The aim of this study is to employ 3D radiomic analyses to pre-operative Computed Tomography (CT) scan images for cases of pancreatic head cancer that underwent surgical resection, to determine whether this information could be used for modelling to predict operative resection margins and potentially guide additional treatment.
REC name
Yorkshire & The Humber - Leeds West Research Ethics Committee
REC reference
22/YH/0103
Date of REC Opinion
21 Apr 2022
REC opinion
Favourable Opinion