POPIN Study Version 1.5
Research type
Research Study
Full title
Prediction of Pregnancy Outcomes Following Induction of Labour
IRAS ID
198121
Contact name
Ranjit Akolekar
Contact email
Sponsor organisation
Medway NHS Foundation Trust
ISRCTN Number
ISRCTN10984408
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Induction of labour (IOL) is one of the most common obstetric procedures and is carried out in 20-30% of pregnancies. More than a third of women having IOL will need either an instrumental delivery or a caesarean section. Currently, the Bishop score, based on findings of vaginal examination, is the most commonly used clinical assessment prior to IOL. Unfortunately, it is subjective and unreliable and its utility at predicting successful vaginal delivery is limited. A model that could accurately predict which women will have a successful induction of labour would be of significant benefit in counselling women prior to induction.
We propose to develop a model that will accurately predict the time from induction to delivery and the risk of caesarean section using a combination of maternal and fetal factors measured at a pre-induction clinic. The biochemical factors measured will include fetal fibronectin and placental alpha-macroglobulin-1, both markers of preterm delivery that have not been robustly studied in an induction of labour context.
We will also systematically measure throughout labour three recently described ultrasound parameters (angle of progression, head-perineum distance, sonographic cervical dilatation) in women undergoing induction in order to assess their utility in predicting operative delivery.REC name
London - Dulwich Research Ethics Committee
REC reference
16/LO/0367
Date of REC Opinion
31 Mar 2016
REC opinion
Further Information Favourable Opinion