POMAR
Research type
Research Study
Full title
Progressions and Outcome of Secondary Mitral Regurgitation - A Prospective Multicentre Study (POMAR Study)
IRAS ID
177898
Contact name
Mark Monaghan
Contact email
Sponsor organisation
CHU Sart Tilman
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Heart failure is a common problem in UK with sizable economic impact. One of the most common complications of heart failure is leaky mitral valve as the valve does not close properly because of the change in shape and size of the left chamber of the heart. This is called mitral regurgitation which has dismal impact on survival. The more severe the mitral regurgitation the more worse the prognosis. Physical examination is rather insensitive in both detecting this condition and in determining the severity.
Ultrasound of the heart which is called echocardiography is normally used to diagnose mitral regurgitation. There has been focus on improving our ability in quantifying mitral regurgitation. The current technique used is two dimensional (2D) echocardiography , however they have their own limitations. Three dimensional (3D) echocardiography has been used in clinical practice in recent years in order to overcome some of these limitations. 3D echocardiography provides a better visualisation of the cardiac valves and therefore more accurate assessment of valve diseases such as mitral regurgitation. In this study, we assess the severity of mitral regurgitation with both 2D and 3D echocardiography in a series of patients with heart failure. The aim of the study will be to evaluate the impact of 3D assessment of mitral regurgitation on prognosis of patients with heart failure.
We will also compare the 3D method with 2D technique to assess the advantages of 3D over traditional 2D based methods. In addition, we will explore the effect of combining the traditional 2D method and 3D follow up of heart failure patients. We also will assess the rate of progression of mitral regurgitation and its effect on left heart chamber.
REC name
South Central - Berkshire Research Ethics Committee
REC reference
15/SC/0356
Date of REC Opinion
22 Jun 2015
REC opinion
Favourable Opinion