Polyp evolution
Research type
Research Study
Full title
Retrospective, case-control study to investigate molecular differences between ‘progressor’ and ‘non-progressor’ adenomas
IRAS ID
245879
Contact name
Anisha Suka
Contact email
Sponsor organisation
London North West University Healthcare NHS Trust
Duration of Study in the UK
4 years, 0 months, 1 days
Research summary
This is a retrospective case- control study to identify gene and RNA expression and genetic/molecular differences between adenomatous polyps in patients who subsequently develop a cancer (progressor) and patients who do not develop a cancer (non-progressor).\n\nFFPE (formalin fixed paraffin embedded) blocks of tissue from these adenomas will be analysed and the DNA will be extracted from multiple sites (via micro-dissection). Next generation sequencing involving whole-genome sequencing panels will be used to determine the genotypes (and expression profiles) of these adenomas. \n\nThe aim of this work is to improve the prediction of future colorectal cancer risk, following the complete excision of an adenoma. This study will determine molecular markers, which can be used for clinical risk stratification. \n
REC name
South West - Cornwall & Plymouth Research Ethics Committee
REC reference
18/SW/0110
Date of REC Opinion
1 Jun 2018
REC opinion
Further Information Favourable Opinion