POLYMATH- Pathogenesis Of Lymphoma for Therapy
Research type
Research Study
Full title
A comprehensive analysis of the pathogenesis of B cell lymphomas including the role of the microenvironment
IRAS ID
181189
Contact name
Paul Murray
Contact email
Sponsor organisation
University of Birmingham
Duration of Study in the UK
3 years, 2 months, 31 days
Research summary
New therapies are required for high grade aggressive B cell lymphomas. We will establish new models of these diseases using primary B cells taken from tonsils/apheresis cones, and tumour cells taken from affected lymph nodes. Using primary normal B cells we will deliver oncogenes and study their cell signalling effects, providing an opportunity to examine the early steps in tumour development. Using cells isolated from primary tumour tissues we will explore how these tumours grow in immunodeficient mice and study the contribution of the tumour microenvironment to tumour establishment and progression. Finally, we will interrogate an existing archive of paraffin-embedded lymphoma samples to determine the extent to which any changes we observe in vitro and in the animal models recapitulate human disease. We expect this Programme of research to not only provide a better understanding of B cell lymphoma development, but also to lead to new therapies and also better animal models for testing these therapies.
REC name
West Midlands - Black Country Research Ethics Committee
REC reference
16/WM/0037
Date of REC Opinion
9 May 2016
REC opinion
Further Information Favourable Opinion