Pod-NET
Research type
Research Study
Full title
Role of CCK2 receptor and gastrin/CCK2R signalling in the pathogenesis of duodenal neuroendocrine tumours (Pod-NET).
IRAS ID
264697
Contact name
Mark Pritchard
Contact email
Sponsor organisation
University of Liverpool
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Duodenal neuroendocrine tumours(d-NETs) are relatively rare tumours of the upper gastrointestinal tract and we do not fully understand how they are formed. We are investigating potential mechanisms that lead to the formation of these tumours. This means that in the future we could use certain drugs to treat or suppress these type of tumours.
In this new research, we wish to obtain blood and tissue samples from newly diagnosed patients as well as access tissue samples from previously diagnosed patients.
With the patient’s permission, we would like to use blood, new and old tissue samples and look at various proteins and genes they express and find possible interactions that lead to d-NET formation.
We aim to recruit about 50 patients who will be having a gastroscopy (camera into the stomach/duodenum) for diagnosis or follow up, 25 patients with d-NETs and 25 controls. We would also like access to old surplus tissue samples from about 50 patients already diagnosed with d-NETs. Patients will be identified and recruited for the study from the neuroendocrine clinic and endoscopy unit at the Royal Liverpool University Hospital.REC name
North West - Liverpool Central Research Ethics Committee
REC reference
19/NW/0671
Date of REC Opinion
21 Feb 2020
REC opinion
Further Information Favourable Opinion