PMPR and Chlorhexidine on Periodontal Disease
Research type
Research Study
Full title
The Effect of Professional Mechanical Plaque Removal (PMPR) and Chlorhexidine Mouthwash on Salivary and Acquired Enamel Pellicle (AEP) Proteins and Vascular Function and Inflammation in People with Periodontal Disease.
IRAS ID
351521
Contact name
Saagarika Sharma
Contact email
Sponsor organisation
University of Portsmouth
Clinicaltrials.gov Identifier
NA, NA
Duration of Study in the UK
3 years, 0 months, 0 days
Research summary
Gum disease, known as periodontal disease, is a long-term inflammation of the gums and bone around teeth, leading to tooth loss and is also linked to other health problems, including heart disease. Additionally, salivary proteins play a role in maintaining oral health. For example, a protective layer called the salivary pellicle (SP) forms on teeth after tooth brushing and helps defend against harmful bacteria. Nitrate-reducing bacteria (NRB) are also present in saliva and play a role in oral and cardiovascular health by converting nitrate to nitric oxide (NO). This compound supports blood vessel health and overall cardiovascular function. Therefore, NRB's abundance is linked to lower blood pressure and improved cardiovascular health. Standard treatments for gum disease include deep cleaning (also called professional mechanical plaque removal, or PMPR), and sometimes chlorhexidine (CHX) mouthwash is used with PMPR to help reduce mouth bacteria. However, while CHX is effective against plaque, a sticky film of bacteria on the surface of your teeth, it may reduce the activity of “nitrate-reducing” bacteria (NRB), which are important for producing nitric oxide (NO).
This study investigates the impact of deep cleaning (PMPR) with and without Chlorhexidine mouthwash on salivary and SP proteins, as well as blood vessel function, in people who have gum disease. By examining these links, we hope to understand better how oral care practices might influence overall health, especially heart health.REC name
Wales REC 6
REC reference
25/WA/0160
Date of REC Opinion
10 Jul 2025
REC opinion
Further Information Favourable Opinion