PLUM
Research type
Research Study
Full title
Pustular psoriasis: eLucidating Underlying Mechanisms
IRAS ID
201357
Contact name
Catherine Smith
Contact email
Sponsor organisation
Guy's and St Thomas' NHS Foundation Trust
Duration of Study in the UK
4 years, 11 months, 31 days
Research summary
Pustular forms of psoriasis are characterised by painful, intensly inflamed, red skin studded with sterile pustules. The disease may be chronic and localised, typically to the hands and feet, or, more rarely, more generalised across the body and potentially life-threatening. Although pustular psoriasis accounts for less than 10% of psoriasis cases it consistently ranks highest among all variants in terms of symptoms and functional impairment. There is recent evidence, including work from our own group, to suggest that distinct underlying genetic and molecular pathways found in patients with pustular disease could be responsible for this particular disease presentation. The poor response to therapies used to great effect in other types of psoriasis may also be expla
In PLUM we aim to identify and understand the genes that may have an influence on the development of pustular psoriasis, related immune pathways and responses to treatment. We will recruit patients, disease controls, healthy volunteers and relations of patients and invite them to donate blood samples, and optional skin and hair pluck samples.
REC name
London - London Bridge Research Ethics Committee
REC reference
16/LO/2190
Date of REC Opinion
30 Jan 2017
REC opinion
Further Information Favourable Opinion