Ploidy and stroma in early rectal cancer
Research type
Research Study
Full title
An observational study to correlate the results of ploidy and stroma analysis with prognosis in early rectal cancer
IRAS ID
195159
Contact name
Chris Cunningham
Contact email
Sponsor organisation
Oxford University Hospitals NHS Foundation Trust
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Early rectal cancer can be removed by minimally-invasive surgery, and the standard pathological assessment of the removed tumour gives valuable information about how advanced the tumour is. This information is very important in indicating whether the cancer is likely to recur, and therefore in advising the patient after surgery whether further treatment is advisable, and if not, what is the most appropriate follow-up regime. However there is still a lot of uncertainty in these predictions about recurrence of the cancer, and better tests are being sought. This study aims to look at two further pathology tests, ploidy and stroma ratio in the tumour, and compare these test results with outcome in patients who have had an early rectal cancer removed. This will allow us to assess whether these two tests can give greater accuracy in predicting outcome. If so, we would be better able to advise patients with early rectal cancer about their prognosis and further management.
REC name
West Midlands - South Birmingham Research Ethics Committee
REC reference
16/WM/0443
Date of REC Opinion
28 Oct 2016
REC opinion
Further Information Favourable Opinion