Platelet-rich plasma and fat graft for diabetic ulcer
Research type
Research Study
Full title
A Randomised Controlled Trial to Compare Platelet-Rich Plasma and Autologous Fat Graft for Diabetic Ulcer
IRAS ID
205563
Contact name
Afshin Mosahebi
Contact email
Sponsor organisation
University College London
Duration of Study in the UK
2 years, 9 months, 1 days
Research summary
Platelet-rich plasma (PRP) is a rich source of growth factors important for tissue repair and regeneration. PRP is increasingly used to treat chronic, difficult-to-heal wounds with good clinical outcome. Autologous fat graft, on the other hand, is a rich source of mesenchymal stem cells (MSCs) which is vital in tissue regeneration. Autologous fat grafting is performed extensively in reconstructive surgery with excellent safety profile and clinical outcome. Both the PRP and fat graft are currently being used in clinical practise and increasingly used in wound management, however the difference in healing outcome between these two procedures is not known.
We wish to compare these two clinical procedures; PRP versus fat graft for wound healing, and to further evaluate the outcome with PRP and fat graft in combination. We hypothesise that the combination of PRP and fat graft would speed and improve healing further than using these procedures in isolation.REC name
London - Chelsea Research Ethics Committee
REC reference
16/LO/2261
Date of REC Opinion
21 Dec 2016
REC opinion
Favourable Opinion