Platelet function during cardiac surgery with moderate hypothermic CPB
Research type
Research Study
Full title
An assessment of platelet function during cardiac surgery with moderate hypothermic cardiopulmonary bypass.
IRAS ID
109530
Contact name
Lynne Anderson
Contact email
Sponsor organisation
Golden Jubilee National Hospital
Duration of Study in the UK
0 years, 4 months, 1 days
Research summary
Cardiac surgery as a speciality is one of the highest users of donated blood and blood products. The use of a technique called cardiopulmonary bypass is necessary for most major cardiac surgeries and as such this process leads to the development of coagulopathies and bleeding due to several reasons. These include haemodilution from a large bypass prime of crystalloid/colloid fluid, fibrinolysis from contact with the artificial surfaces of the bypass circuit, direct platelet damage from the bypass pump, the effects of anti-platelet medication and also heparin-protamine interactions. Point of care testing has become invaluable in recent times in diagnosis of coagulopathies however these analysers tend to measure patient's actual temperature at 37 degrees celsius regardless of actual body temperature. This may not always be appropriate as it fails to accurately present correct results. This may be of additional relevance as patients tend to cool after seperation from the bypass machine despite being fully rewarmed, many patients return to ITU mildly hypothermic. It is widely recognised that cardiopulmonary bypass decreases platelet function; hypothermia, however mild, may exacerbate this dysfunction.
The aim of this study is to assess platelet function at 32 and 37 degrees celsius. A final sample will be taken 1 hour post admission into the ITU and analysed. A total of 36ml of blood will be taken from each patient over 5 sampling points and analysed using Multiplate impedance aggregometry and TEG/ROTEM thromboelastography at several time points.
The study size will be limited to 25 patients between 18-80 years of age. They will be chosen from patients undergoing first time coronary artery bypass grafting surgery. Once the final sample has been drawn the patients involvement in the project will have ended.REC name
West of Scotland REC 5
REC reference
15/WS/0025
Date of REC Opinion
16 Feb 2015
REC opinion
Further Information Favourable Opinion