Platelet-Cancer cell adhesion v02 REC
Research type
Research Study
Full title
Interaction of platelets with cancer cells and endothelial cells
IRAS ID
209986
Contact name
Anne Ridley
Contact email
Duration of Study in the UK
4 years, 0 months, 1 days
Research summary
When cancers spread from one part of the body to another, they are difficult to cure. They spread by entering the bloodstream, which carries them to other sites. One key step in cancer spreading is the attachment of cancer cells to endothelial cells lining the blood stream. Cancer cells can subsequently get out of blood vessels and grow as secondary tumours, known as metastases, in the different sites in the body. Small cells called platelets in the bloodstream can attach to cancer cells and/or endothelial cells to promote cancer cell metastasis. However, the molecules that allow platelets to attach to cancer cells and/or endothelial cells are not well characterised. We aim to identify these molecules, and for this we require a source of human platelets, which we will purify from human blood. We hope our research will help to find new treatments to reduce metastasis in cancer patients.
REC name
South Central - Oxford B Research Ethics Committee
REC reference
16/SC/0458
Date of REC Opinion
18 Aug 2016
REC opinion
Favourable Opinion