PLANE-DFU
Research type
Research Study
Full title
Plantar Load Analysis of Neuropathic and nEuroischaemic Diabetes-related Foot Ulceration (PLANE-DFU): Investigating Plantar Pressure and Shear in Neuropathic versus Neuroischaemic Diabetes-Related Foot Ulceration
IRAS ID
355867
Contact name
Christopher Ashmore
Contact email
Sponsor organisation
Leeds Teaching Hospitals NHS Trust
Duration of Study in the UK
0 years, 8 months, 1 days
Research summary
Diabetes-related foot ulceration (DFU) describes serious wounds on the foot that can lead to infection, amputation, and even loss of life. These ulcers occur due to a combination of factors, including poor circulation (peripheral arterial disease or PAD), nerve damage (sensory neuropathy), and high pressure or rubbing on the foot.
When people walk, their feet experience two types of forces: pressure (the downward force of body weight) and shear (sideways rubbing forces). PAD is known to increase the risk of DFUs, but it is unclear how much it affects these forces or contributes to changes in the fat pad—a natural cushion under the foot that helps absorb impact.
This study aims to compare foot pressure, strain (a combination of pressure and shear forces), and fat pad thickness in people with and without PAD. Using specialised pressure-measuring insoles (Pedar™) and a new strain analysis system (STAMPS), we will measure how forces are distributed across the sole of the foot. Ultrasound scans will assess whether the fat pad is thinner in people with PAD.
By understanding these differences, we hope to improve strategies for preventing DFU in people with diabetes, potentially leading to better identification of those at risk and offering treatments to reduce pressure and shear forces on the foot.
REC name
South Central - Berkshire B Research Ethics Committee
REC reference
25/SC/0253
Date of REC Opinion
12 Sep 2025
REC opinion
Further Information Favourable Opinion