An observational-based registry of baseline PKG in Parkinson's disease
K Ray Chaudhuri
King's College London
Duration of Study in the UK
2 years, 0 months, 6 days
Objective monitoring is common place in neurological disorders such as epilepsy or neuropathy. In recent years, objective recording has been receiving an increasing interest in Parkinson’s disease (PD) in clinical and research settings as well. The Parkinson’s KinetiGraph™ (PKG) is a validated system consisting of algorithms operating on a wrist-worn device that objectively measures different motor states of PD patients throughout the day. The PKG data logger contains a rechargeable battery, a triaxial accelerometer, a reminder signal to prompt patients to take their PD medication, a button to be pressed for recording of medication intake and a capacitive sensor to detect removal from the wrist. The PKG recording is used by Neurology specialists worldwide as part of their management program as it is an objective way of recording PD patients’ movements and analysing patients’ response to the medication. It provides a number of different measures that can be useful as a complement to clinical interpretation of motor and non-motor symptoms.
It is widely acknowledged that PD patients constitute a very heterogeneous population with a wide range of motor and non-motor symptoms, disease severity and progression, and available therapies. We think that deepening our understanding using the above mentioned technology in a wide range of clinical settings will contribute to improve our knowledge and expertise in managing PD patients.
We aim to creating an observational-based registry that collects standard clinical scales and questionnaires (the so-called subjective measurement) and PKG recordings (an objective measurement) used in clinical practice from a large sample of PD patients.
London - Riverside Research Ethics Committee
Date of REC Opinion
16 Aug 2017