PIRATE
Research type
Research Study
Full title
Pleural Infection Registry and Translational Endpoint Study (PIRATE STUDY)
IRAS ID
316258
Contact name
Philip Short
Contact email
Sponsor organisation
NHS Tayside
Duration of Study in the UK
5 years, 0 months, 1 days
Research summary
Pleural disease is a common reason for admission to hospital and patients often require samples to be taken from the pleural space to exclude infection and inflammation. Chest drainage and antibiotic treatment are used to resolve pleural infection but despite this, surgical treatment or prolonged therapy are often required. Development of anti-inflammatory treatments to help to resolve pleural disease is needed. To achieve this we need to understand the inflammatory response in the pleural space.
This study will aim to characterise inflammation in the pleural space and whether there could be a potential role for anti-inflammatory treatment in the management of pleural infection and inflammation.
This is an observational cohort study at a singe site. We will aim to recruit a total of 250 people aged 18 and over. 100 with pleural infection, 100 with pleural effusions who do not have confirmed or suspected pleural infection and 50 controls who have no indication of current infection. All participants will be inpatients in NHS Tayside. We will obtain samples of pleural fluid from the pleural effusion group at a time when it is being taken for clinical reasons. We will also take a blood sample from all participants. This is a single visit only study where we will collect samples, demographics and medical history. We will also ask for consent for longer term (5 years) data linkage to electronic health records to allow future outcomes to be determined.
REC name
London - Fulham Research Ethics Committee
REC reference
22/PR/1668
Date of REC Opinion
19 Jan 2023
REC opinion
Further Information Favourable Opinion