PINNACLE- Retrospective study
Research type
Research Study
Full title
Deciphering AMD by deep phenotyping and machine learning - PINNACLE retrospective study
IRAS ID
259360
Contact name
Andrew Lotery
Contact email
Sponsor organisation
University of Southampton
Duration of Study in the UK
4 years, 10 months, 31 days
Research summary
Age-Related Macular Degeneration is the commonest cause of blindness in the elderly. By 2020, 200 million people are expected to be affected with AMD, increasing to nearly 300 million by 2040. Unfortunately, doctors don’t know who will progress to the sight threatening stage of the disease. Some patients progress slowly or not at all and others quickly.
We can teach computers to analyse high resolution images of the inside of the eye. From UK Biobank and local eye clinics, we have access to hundreds of thousands of such images from people with AMD as well as those without. These images will allow us to train computers to identify what eye changes appear in patients with AMD. Alongside these images we also have access to DNA results that we can match up to the images to see whether specific DNA changes affect the progression of AMD in individuals.REC name
Wales REC 4
REC reference
19/WA/0079
Date of REC Opinion
20 Mar 2019
REC opinion
Favourable Opinion