Pilot study to determine the effect of dialysis on intestinal biome
Research type
Research Study
Full title
Pilot study to determine the effect of different dialysis treatment modalities and diet on gastrointestinal bacteria and azotaemic toxins
IRAS ID
180229
Contact name
A Davenport
Contact email
Sponsor organisation
UCL
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Dialysis is a treatment for patients with chronic kidney disease. Waste products of metabolism which build up in the blood in patients with chronic kidney disease then pass from the blood into the fresh dialysate by a process of diffusion whereby molecules move from a high concentration (the patient’s blood) to one of low concentration (the fresh dialysate),and are removed. However some of the toxins that accumulate are bound to proteins and very poorly cleared by diffusion. Several of these protein bound toxins are made by bacteria in the intestine. One potential way of reducing these toxins would be to alter bacterial populations in the intestine. However little is know about intestinal bacteria in patients with chronic kidney disease and as such we propose a pilot study to learn whether there are differences in intestinal bacteria in different groups of patients with chronic kidney disease
REC name
East of England - Cambridge Central Research Ethics Committee
REC reference
15/EE/0219
Date of REC Opinion
1 Jun 2015
REC opinion
Favourable Opinion