Pilot study of AS OCT in Paediatric Uveitis
Research type
Research Study
Full title
Objective assessment of anterior segment in children with uveitis: a pilot study
IRAS ID
215685
Contact name
Ameenat Lola Solebo
Contact email
Sponsor organisation
UCL GOS ICH
Duration of Study in the UK
0 years, 1 months, 9 days
Research summary
Paediatric uveitis (inflammation inside the eye) is an uncommon disorder which carries the risk of blindness. In the most common form of the disorder, anterior uveitis, the front chamber of the eye is affected. Inadequate treatment of active inflammation has been shown to be related to poor outcome. Currently, disease activity is assessed using bio-microscopic examination of the anterior chamber of the eye, undertaken by an ophthalmologist (eye doctor), who grades the degree of inflammation using an internationally agreed scale. This scale has not been validated for use in children, and when used in adults it is open to considerable variability between doctors.
A new adaptation of an existing imaging technology, optical coherence tomography, has been shown to be able to detect and measure inflammation inside the eye in animal studies and small pilot studies in adults. Another new adaptation, OCT angiography, can image blood flow within the different tissues in the eye. OCT cameras are in common clinical use to assess inflammation in the back of the eye (choroid and retina). We now propose a pilot study to examine the feasibility of OCT detection of anterior chamber activity, and OCTA classification of disease type, in children. The study will recruit children over a two week period, as we have negotiated the loan of an OCTA instrument for this period. Results from this study will be used to develop larger scale studies of acceptability, feasibility and clinical validity of OCT/OCTA assessment of paediatric uveitis activity.REC name
London - Stanmore Research Ethics Committee
REC reference
18/LO/0252
Date of REC Opinion
13 Apr 2018
REC opinion
Further Information Favourable Opinion